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M9490448.TXT
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1994-09-19
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Document 0448
DOCN M9490448
TI The mating-type region of Schizosaccharomyces pombe contains an
essential gene encoding a protein homologous to human modulators of HIV
transactivation.
DT 9411
AU Michael H; Schmidt H; Fleck O; Gutz H; Liedtke C; Lorentz A; Ostermann
K; Institut fur Genetik, Technische Universitat Braunschweig,; Germany.
SO Gene. 1994 Aug 5;145(2):205-10. Unique Identifier : AIDSLINE
GENBANK/U02280
AB In Schizosaccharomyces pombe, an intrachromosomal crossover between the
mating type (MT) expression locus and one of the silent donor cassettes
is lethal due to the loss of the intervening L region. The region
contains one essential gene, let1. This gene was cloned and sequenced.
The deduced amino acid (aa) sequence of let1 shows extensive homologies
with SUG1 from Saccharomyces cerevisiae. Significant homologies were
also found with the human HIV transactivation modulators, MSS1 and
TBP-1, as well as with subunit 4 of the mammalian 26 S protease. The
data indicate that let1 is a member of a recently defined multigene
family of ATPases.
DE Adenosinetriphosphatase/CLASSIFICATION/*GENETICS Amino Acid Sequence
Base Sequence Cloning, Molecular Comparative Study Fungal
Proteins/*GENETICS Genes, Fungal/*GENETICS Genes, Lethal/*GENETICS
Human HIV/GENETICS Molecular Sequence Data Peptides/GENETICS
Schizosaccharomyces/*GENETICS Sequence Analysis, DNA Sequence
Homology, Amino Acid Support, Non-U.S. Gov't Trans-Activation
(Genetics) JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).